Rubrik: Wissenschaft
(Treffer aus pharmind, Nr. 08, Seite 1159 (2017))
Thundimadathil J | McGee C
Chemical Glycosylation of Peptides / Thundimadathil and McGee • Chemical Glycosylation · Thundimadathil J, McGee C · Bachem Americas, Inc., Torrance, USA
Whereas recombinant synthesis of glycosylated peptides and proteins yields heterogeneous products, homogeneous glycoforms with potential for better defined bioactivity can be obtained by complex chemical methods. A new technology permits straightforward selective glycosylation via incorporation of amino acid building blocks bearing glycans during the course of solid phase peptide synthesis (SPPS) and liquid phase peptide synthesis (LPPS). A proprietary library of highly purified and well characterized glycan derivatives of amino acids is now commercially available to support development of peptides and proteins with enhanced physicochemical and pharmacological properties.